Expanding from 2021, which had 300 base cards, the 2022 Panini Prestige Football checklist offers a 400-card base set. This includes 90 base rookie cards and 10 rookie card short prints.

Collectors can also look for standard Xtra Points parallels along with holographic Premium editions.

Returning inserts consist of the comic-style Heroes, star-filled Franchise Favorites, and Season's Greetings, with a design similar to a postcard. These add an assortment of parallels.